![]() Mitochondrial dynamics have an important physiological significance. This dynamic balance is mitochondrial dynamics ( Mireille and Slack, 2018). Through the synergistic effect of several dynamic related proteins, the number, morphology, and overall connectivity of mitochondria are adjusted to meet the needs of cells in different environments. Mitochondria are in a dynamic balance of high division and fusion in cells. Additionally, they participate in cell processes such as differentiation, metabolism, apoptosis, signal transduction, and natural immunity ( Trifunovic and Bratic, 2010 Zhang et al., 2018). Mitochondria are important organelles in cells, which produce ATP through oxidative phosphorylation and provide energy for metabolism of various substances in cells. By regulating the metabolism and physiological processes of the cell, a virus can change the structure and function of the cells to maintain a living environment that is conducive to virus proliferation ( Xia et al., 2014). It uses the host cell’s metabolic system to synthesize nucleic acids and proteins. Herein, we discuss the mechanism of the virus-induced mitochondrial dynamics imbalance and its subsequent effects on the body, which will help to improve our understanding of the relationship between mitochondrial dynamics and viral infection and its importance.Ī virus is a microbe that parasitizes on cells. This creates an intracellular environment that is conducive to viral proliferation and begins the process of its own infection and causes further damage to the body. After viral infection, the dynamic balance of the host cell mitochondria is disturbed, affecting the processes of energy generation, metabolism, and innate immunity. This dynamic balance is highly susceptible to various stress environments, including viral infection. This maintains the stability of their morphological functions. Mitochondria are highly dynamic organelles that maintain the dynamic balance of split-fusion via kinetic proteins. 2The College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.1Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.All rights reserved.Zhihua Ren 1 † Xiaojie Zhang 1 † Ting Ding 1 Zhijun Zhong 1 Hui Hu 2 Zhiwen Xu 1 * Junliang Deng 1 * We suggest that deeper understanding of the regulatory mechanisms within this system and downstream implications could benefit in understanding and intervention of these conditions.Īge-related disease Aging Fission Fusion Mitochondrial dynamics.Ĭopyright © 2020 The Author(s). Finally, we discuss the current evidence implicating these processes in age-related human pathologies, such as neurodegenerative or cardio-metabolic diseases. Here, we discuss the mechanisms of mitochondrial fission and fusion, the current evidence of their role in aging of multicellular organisms, and how these connect to cell cycle regulation, quality control, and transmission of energy status. There does exist, however, a large body of evidence connecting mitochondrial dynamics to other aging-related cellular processes and implicates them in a number of human diseases. While many mitochondrial processes are already characterized in relation to aging, specific evidence in multicellular organisms causally linking mitochondrial dynamics to the regulation of lifespan is limited. Mitochondria separate and merge using fission and fusion processes in response to changes in energy and stress status. Crucial to mitochondrial regulation is the dynamic nature of their network structure. Dysregulation of mitochondrial function is one of the classical hallmarks of aging, and mitochondrial interventions have repeatedly been shown to improve outcomes in age-related diseases. The mitochondria is the major hub to convert energy for cellular processes.
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